About Dr. Geeta Rai
Geeta Rai, Ph.D
Assistant Professor (Stage 3)
Department of Molecular & Human Genetics
Institute of Science
Banaras Hindu University,Varanasi- 221005
Our current research program comprises of several independent but synergistically interacting projects with major focus in three domains:
- Autoimmune disease Systemic Lupus Erythematosus (SLE).
- Defective mechanisms of the innate immunity in low birth weight (LBW) newborns.
- Stem cell studies to develop better tools for regenerative medicine.
- 1.My research contribution in SLE initiates from development of a novel disease model and extends to identification, optimization and evaluation of disease processes aimed at amelioration of the disease state in human beings. The salient research outputs have been, elucidation of role of Toll like Receptors in paradigm of diverse clinical manifestations in SLE (Patent, 2013(a)., best oral presentation award, Immunocon 2012). Significant efforts have led to successful characterization of novel markers in SLE using genomic and proteomic approaches. Results of miRNA and global transcriptome sequencing studies have helped provide a strong basis for dintinguishing SLE in 3 distinct subgroups with a potential of impacting treatment modality.
- 2.Transcriptomic and proteomic studies involving newborns have resulted in identification of defective immune pathways responsible for increased susceptibility of LBW newborns towards life threatening infections and mortality (GP Talwar young scientist award, Immunocon 2013). Our observations on impaired Neutrophil Extra trap (NET) formation in LBW newborns (Best oral presentation award, Immunocon 2013’) led to development of novel formulation to improve immune efficiency and NET formation (Patent 2013(b)).
- 3.Our recent research focus in stem cells, has identified defective differentiation of cord blood hematopoetic stem cells in specific group of newborns.
- In addition, we are involved in development of monoclonal Abs and biosimilars and our efforts to manage Dengue fever through immunomodulation have resulted in a novel formulation (Patent 2016). Development of biogenic silver nanoparticles which target and destroy cancer cells has been our most recent research effort (Patent 2017).
Award & Honors
G.P. Talwar Young scientist awardSingh VV, Chauhan SK, Rai R, Soni UK, Ashok Kumar, Rai G. Impaired Genetic Mechanisms of Innate Immunity in Low Birth Weight Newborns. 40th Ann. Conf. of Indian Immunology Society, University of Delhi, North Campus, New Delhi, November 15 -17, 2013; P-30.
Firstprize in oral presentation (2013) Soni UK, Singh VV, Chauhan SK, Rai R, Ashok Kumar, Rai G. Leukotriene B4 receptor regulates Neutrophil Extracellular Trap formation by activation of Gas/Rap1/b-Raf/ERK1/2 signaling pathway. 40th Ann. Conf. of Indian Immunology Society, University of Delhi, North Campus, New Delhi, November 15 -17, 2013; P-60.
Firstprize in oral presentation (2012) Chauhan SK, Singh VV, Rai R, Rai M, Rai G. TLR7 and TLR9 upregulation associates with autoantibodies against specific nuclear targets in systemic lupus erythematosus. 39th Ann. Conf. of Indian Immunology Society, Banaras Hindu University, Varanasi, November 9-11, 2012; P-40.
Secondprize in oral presentation (2012) Soni UK, Singh VV, Chauhan SK, Rai R, Kumar A, Rai G. HL60 differentiation: Highest ROS activity with maximum survivability of neutrophil-like cells achieved after 120 hrs by All Trans Retinoic Acid (ATRA) induction. 39th Ann. Conf. of Indian Immunol.Soc., BHU, Varanasi, November 9-11, 2012; P-59.